Pharmacological Activity of Basic Alkyl Esters of Substituted Pyrrolidine Dicarboxylic Acids

The present communication deals with the local anesthetic activity and toxicity of 16 basic alkyl esters of substituted pyrrolidine dicarboxylic acids.t In an accompanying article5 the intestinal, uterine, and depressor activity of these compounds is presented. Twelve of the compounds were 2, 5-di-(3-diethylaminoethyl) esters and 3 were 2, 5-di-(y-diethylaminopropyl) esters. One was 2-(Zdiethylaminoethyl) and 5-ethyl ester. All of the compounds had aliphatic or aromatic subst.itutions on the nitrogen of the pyrrolidine ring. Methodsh